Identification of distal KIR promoters and transcripts
نویسندگان
چکیده
منابع مشابه
Identification and Characterization of Alternative Promoters, Transcripts and Protein Isoforms of Zebrafish R2 Gene
Ribonucleotide reductase (RNR) is the rate-limiting enzyme in the de novo synthesis of deoxyribonucleoside triphosphates. Expression of RNR subunits is closely associated with DNA replication and repair. Mammalian RNR M2 subunit (R2) functions exclusively in DNA replication of normal cells due to its S phase-specific expression and late mitotic degradation. Herein, we demonstrate the control of...
متن کاملPromoters, transcripts, and regulatory proteins of Mungbean yellow mosaic geminivirus.
Geminiviruses package circular single-stranded DNA and replicate in the nucleus via a double-stranded intermediate. This intermediate also serves as a template for bidirectional transcription by polymerase II. Here, we map promoters and transcripts and characterize regulatory proteins of Mungbean yellow mosaic virus-Vigna (MYMV), a bipartite geminivirus in the genus Begomovirus. The following n...
متن کاملfunctional study of p0 proteins of two cereal yellow dwarf viruses (cydv-rpv and cydv-rps) and identification of their cellular partner
نقش سرکوبگری پروتئین p0 در دو پولروویروس کوتولگی زردی غلات cydv-rpv) و (cydv-rps، متفاوت در شدت بیماریزایی، مورد مطالعه قرار گرفت. نتایج نشان داد که هر دو پروتئین p0 p0cy-rpv) و (p0cy-rps قادر به سرکوب خاموشی آر ان ای ایجاد شده توسط ترادف های تراژن سنس و تکرار معکوس در n. benthamiana هستند. نشان داده شد که هر دو پروتئین p0 می توانند تخریب پروتئین argonaute-1 را تسهیل کنند. علاوه بر این، تمایل م...
Distal CpG islands can serve as alternative promoters to transcribe genes with silenced proximal promoters.
DNA methylation at the promoter of a gene is presumed to render it silent, yet a sizable fraction of genes with methylated proximal promoters exhibit elevated expression. Here, we show, through extensive analysis of the methylome and transcriptome in 34 tissues, that in many such cases, transcription is initiated by a distal upstream CpG island (CGI) located several kilobases away that function...
متن کاملSystematic Identification of Novel Fusion Transcripts
Fusion transcripts are products of chromosomal rearrangements that are frequently involved in carcinogenesis. A genomic translocation event can result in the fusion of two genes. The resulting chimeric gene is transcribed into a fusion transcript which in turn is translated into a fusion protein. In order to identify fusion transcripts systematically and comprehensively, we developed a pipeline...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2006
ISSN: 1466-4879,1476-5470
DOI: 10.1038/sj.gene.6364363